The transgender star - sibling of actors David, Rosanna and Patricia Arquette - died on Sunday morning.
Her other brother Richmond confirmed the news on Facebook with a press release written by Patricia. He said Arquette died while listening to David Bowie's music.
Alexis Arquette appeared in films including Pulp Fiction and The Wedding Singer.
A cause of death was not given.
Boy George tweeted: "R.I.P my sister Alexis Arquette. Another bright light gone out far too soon. Love to the family and all that loved Alexis." Cont.
Story from - BBC News
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